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245	0	0	_aNeuroscience / _cedited by Dale Purves ... [et al.].
250			_a3rd ed.
260			_aSunderland, Massachusetts : _bSinauer Associates, Publishers, _cc2004.
300			_a1 v. (various pagings) : _bcol. ill. ; _c29 cm. + _e1 CD-ROM (4 3/4 in.)
504			_aIncludes bibliographical references and index.
505			_aPreface xvi Acknowledgments xvii Supplements to Accompany Neuroscience xviii Studying the Nervous Systems of Humans and Other Animals 1 (30) Overview 1 (1) Genetics, Genomics, and the Brain 1 (1) The Cellular Components of the Nervous System 2 (2) Neurons 4 (4) Neuroglial Cells 8 (1) Cellular Diversity in the Nervous System 9 (2) Neural Circuits 11 (3) Overall Organization of the Human Nervous System 14 (2) Neuroanatomical Terminology 16 (2) The Subdivisions of the Central Nervous System 18 (2) Organizational Principles of Neural Systems 20 (3) Functional Analysis of Neural Systems 23 (1) Analyzing Complex Behavior 24 (2) Box A Brain Imaging Techniques 25 (1) Summary 26 (5) Unit I NEURAL SIGNALING Electrical Signals of Nerve Cells 31 (16) Overview 31 (1) Electrical Potentials across Nerve Cell Membranes 31 (3) How Ionic Movements Produce Electrical Signals 34 (2) The Forces That Create Membrane Potentials 36 (2) Electrochemical Equilibrium in an Environment with More Than One Permeant Ion 38 (2) The Ionic Basis of the Resting Membrane Potential 40 (3) Box A The Remarkable Giant Nerve Cells of Squid 41 (2) The Ionic Basis of Action Potentials 43 (2) Box B Action Potential Form and Nomenclature 44 (1) Summary 45 (2) Voltage-Dependent Membrane Permeability 47 (22) Overview 47 (1) Ionic Currents Across Nerve Cell Membranes 47 (2) Box A The Voltage Clamp Method 48 (1) Two Types of Voltage-Dependent Ionic Current 49 (3) Two Voltage-Dependent Membrane Conductances 52 (2) Reconstruction of the Action Potential 54 (2) Long-Distance Signaling by Means of Action Potentials 56 (5) Box B Threshold 57 (3) Box C Passive Membrane Properties 60 (1) The Refractory Period 61 (2) Increased Conduction Velocity as a Result of Myelination 63 (2) Summary 65 (4) Box D Multiple Sclerosis 66 (3) Channels and Transporters 69 (24) Overview 69 (1) Ion Channels Underlying Action Potentials 69 (4) Box A The Patch Clamp Method 70 (3) The Diversity of Ion Channels 73 (3) Box B Expression of Ion Channels in Xenopus Oocytes 75 (1) Voltage-Gated Ion Channels 76 (2) Ligand-Gated Ion Channels 78 (1) Stretch- and Heat-Activated Channels 78 (1) The Molecular Structure of Ion Channels 79 (7) Box C Toxins That Poison Ion Channels 82 (2) Box D Diseases Caused by Altered Ion Channels 84 (2) Active Transporters Create and Maintain Ion Gradients 86 (1) Functional Properties of the Na+ / K+ Pump 87 (2) The Molecular Structure of the Na+ / K+ Pump 89 (1) Summary 90 (3) Synaptic Transmission 93 (36) Overview 93 (1) Electrical Synapses 93 (3) Signal Transmission at Chemical Synapses 96 (1) Properties of Neurotransmitters 96 (6) Box A Criteria That Define a Neurotransmitter 99 (3) Quantal Release of Neurotransmitters 102 (1) Release of Transmitters from Synaptic Vesicles 103 (2) Local Recycling of Synaptic Vesicles 105 (2) The Role of Calcium in Transmitter Secretion 107 (3) Box B Diseases That Affect the Presynaptic Terminal 108 (2) Molecular Mechanisms of Transmitter Secretion 110 (3) Neurotransmitter Receptors 113 (3) Box C Toxins That Affect Transmitter Release 115 (1) Postsynaptic Membrane Permeability Changes during Synaptic Transmission 116 (5) Excitatory and Inhibitory Postsynaptic Potentials 121 (2) Summation of Synaptic Potentials 123 (1) Two Families of Postsynaptic Receptors 124 (2) Summary 126 (3) Neurotransmitters and Their Receptors 129 (36) Overview 129 (1) Categories of Neurotransmitters 129 (1) Acetylcholine 129 (8) Box A Addiction 134 (2) Box B Neurotoxins that Act on Postsynaptic Receptors 136 (1) Glutamate 137 (6) Box C Myasthenia Gravis: An Autoimmune Disease of Neuromuscular Synapses 140 (3) GABA and Glycine 143 (4) Box D Excitotoxicity Following Acute Brain Injury 145 (2) The Biogenic Amines 147 (5) Box E Biogenic Amine Neurotransmitters and Psychiatric Disorders 148 (4) ATP and Other Purines 152 (1) Peptide Neurotransmitters 153 (4) Unconventional Neurotransmitters 157 (4) Box F Marijuana and the Brain 160 (1) Summary 161 (4) Molecular Signaling within Neurons 165 (24) Overview 165 (1) Strategies of Molecular Signaling 165 (2) The Activation of Signaling Pathways 167 (1) Receptor Types 168 (2) G-Proteins and Their Molecular Targets 170 (2) Second Messengers 172 (3) Second Messenger Targets: Protein Kinases and Phosphatases 175 (3) Nuclear Signaling 178 (3) Examples of Neuronal Signal Transduction 181 (3) Summary 184 (5) Unit II SENSATION AND SENSORY PROCESSING The Somatic Sensory System 189 (20) Overview 189 (1) Cutaneous and Subcutaneous Somatic Sensory Receptors 189 (3) Mechanoreceptors Specialized to Receive Tactile Information 192 (1) Differences in Mechanosensory Discrimination across the Body Surface 193 (4) Box A Receptive Fields and Sensory Maps in the Cricket 195 (1) Box B Dynamic Aspects of Somatic Sensory Receptive Fields 196 (1) Mechanoreceptors Specialized for proprioception 197 (2) Active Tactile Exploration 199 (1) The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column--Medial Lemniscus System 199 (3) The Trigeminal Portion of the Mechanosensory System 202 (1) Box C Dermaomes 202 (1) The Somatic Sensory Components of the Thalamus 203 (1) The Somatic Sensory Cortex 203 (3) Higher-Order Cortical Representations 206 (2) Box D Patterns of Organization within the Sensory Cortices: Brain Modules 207 (1) Summary 208 (1) Pain 209 (20) Overview 209 (1) Nociceptors 209 (2) Transduction of Nociceptive Signals 211 (2) Box A Capsaicin 212 (1) Central Pain Pathways 213 (7) Box B Referred Pain 215 (3) Box C A Dorsal Column Pathway for Visceral Pain 218 (2) Sensitization 220 (4) Box D Phantom Limbs and Phantom Pain 222 (2) Descending Control of Pain Perception 224 (1) The Placebo Effect 224 (1) The Physiological Basis of Pain Modulation 225 (2) Summary 227 (2) Vision: The Eye 229 (30) Overview 229 (1) Anatomy of the Eye 229 (2) The Formation of Images on the Retina 231 (3) Box A Myopia and Other Refractive Errors 232 (2) The Retina 234 (2) Phototransduction 236 (4) Box B Retinitis Pigmentosa 239 (1) Functional Specialization of the Rod and Cone Systems 240 (4) Box C Macular Degeneration 243 (1) Anatomical Distribution of Rods and Cones 244 (1) Cones and Color Vision 245 (4) Box D The Importance of Context in Color Perception 247 (2) Retinal Circuits for Detecting Luminance Change 249 (5) Box E The Perception of Light Intensity 250 (4) Contribution of Retinal Circuits to Light Adaptation 254 (3) Summary 257 (2) Central Visual Pathways 259 (24) Overview 259 (1) Central Projections of Retinal Ganglion Cells 259 (4) Box A The Blind Spot 262 (1) The Retinotopic Representation of the Visual Field 263 (4) Visual Field Deficits 267 (2) The Functional Organization of the Striate Cortex 269
520			_aA comprehensive textbook created primarily for medical and premedical students. Text boxes, new and revised, highlight topics of special interest relevant to the chapter topics; these include discussions of the major neurological diseases, research methods, and the relevant animal models. Also includes additional neuroanatomical content, including two appendices: (1) The Brainstem and Cranial Nerves, and (2) Vascular Supply, the Meninges, and Ventricles. Sylvius for Neuroscience: Visual Glossary of Human Neuroanatomy (CD included with every copy) is an interactive reference guide to the human nervous system
650		0	_aNeurosciences. _934
650	1	2	_aNervous System Physiology.
650	2	2	_aNeurochemistry.
700	1		_aPurves, Dale...[.et al]
856	4	1	_3Table of contents _uhttp://www.loc.gov/catdir/toc/ecip0415/2004003973.html
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