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007			cr |||||||||||
008			160210s2016 gw |||| o |||| 0|eng
010			_a 2019768690
020			_a9783319280981
024	7		_a10.1007/978-3-319-28098-1 _2doi
035			_a(DE-He213)978-3-319-28098-1
040			_aDLC _beng _epn _erda _cKENKMTC
050			_aRM301.5.B384 _b2008
072		7	_aPSF _2bicssc
072		7	_aPSF _2thema
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aBanfalvi, Gaspar, _eauthor.
245	1	0	_aPermeability of Biological Membranes / _cby Gaspar Banfalvi.
250			_a1st ed. 2016.
300			_a1 online resource (XI, 263 pages 94 illustrations, 42 illustrations in color.)
505	0		_aPrelims -- Biological membranes -- Permeability of membranes -- Methods of permeabilization -- Applications of permeabilization -- Index.
520			_aThis book deals with biological membranes, focuses on permeabilization and pays particular attention to reversible permeabilization to maintain the viability and physiological conditions of the cells. Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins. The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation. The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.
650		0	_aCell biology.
650		0	_aLipids.
650		0	_aNucleic acids.
650	1	4	_aCell Biology.
650	2	4	_aLipidology.
650	2	4	_aNucleic Acid Chemistry.
776	0	8	_iPrint version: _tPermeability of biological membranes _z9783319280967 _w(DLC) 2016932313
776	0	8	_iPrinted edition: _z9783319280967
776	0	8	_iPrinted edition: _z9783319280974
776	0	8	_iPrinted edition: _z9783319802718
906			_a0 _bibc _corigres _du _encip _f20 _gy-gencatlg
942			_2lcc _cBK _e2nd Edition _hRM301.5.B384 _i2008 _xKM
999			_c13948 _d13948