TY - BOOK AU - Patrick,Graham L. TI - An introduction to medicinal chemistry SN - 9780199697397 (pbk.) AV - RS403 .P38 2013 U1 - 615.1/9 23 PY - 2013/// CY - Oxford PB - Oxford University Press KW - Pharmaceutical chemistry N1 - Includes Bibliographical references and Index; Drugs and drug targets an overview Drug targets : structure and function Protein structure and function Enzymes: structure and function Receptors: structure and function Receptors and signal transduction Nucleic acids: structure and function Pharmacodynamics and pharmacokinetics Enzymes as drug targets Receptors as drug targets Nucleic acids as drug targets Miscellaneous drug targets Pharmacokinetics and related topics Statins Drug discovery, design, and development Drug discovery: finding a lead Drug design: optimizing target interactions Drug design: optimizing access to the target Getting the drug to market The design of ACE inhibitors Artemisinin and related antimalarial drugs The design of oxamniquine Tools of the trade Combinatorial synthesis Computers in medicinal chemistry Quantitative structure-activity relationships (QSAR) De novo design of a thymidylate synthase inhibitor Selected topics in medicinal chemistry Antibacterial agents Antiviral agents Anticancer agents Cholinergics, anticholinergics, and anticholinesterases Drugs acting on the adrenergic nervous system Opioid analgesics Antiulcer agents Steroidal anti-inflammatory agents Design of a novel antidepressant ER -