Methods of cancer diagnosis, therapy, and prognosis: General methods and overviews, lung carcinoma, and prostate carcinoma/

Includes bibliographical references and index.

PART I GENERAL METHODS AND OVERVIEWS 1. METABOLIC TRANSFORMATIONS OF MALIGNANT CELLS (AN OVERVIEW) Leslie C. Costello and Renty B. Franklin INTRODUCTION DEFINING A MALIGNANT CELL: A PARASITIC EXISTENCE THE IN SITU ENVIRONMENT OF THE MALIGNANT CELL DICTATES ITS METABOLISM TUMOR CELL PROLIFERATION: METABOLIC PATHWAYS FOR ITS ACHIEVEMENT COUPLING OF GLYCOLYSIS VIA CITRATE TO DE NOVO LIPOGENESIS/CHOLESTEROGENESIS OPERATION OF THE KREBS CYCLE IN TUMOR CELLS GLUTAMINOLYSIS AS AN ALTERNATE OR ADDITIONAL PATHWAY IN TUMOR CELLS OPERATION OF THE KREBS CYCLE IN TUMOR CELLS APPLICATION OF MOLECULAR GENETICS AND PROTEOMICS TO TUMOR CELL INTERMEDIARY METABOLISM ACKNOWLEDGEMENT REFERENCES 2. DETECTION OF RECURRENT CANCERBY RADIOLOGICAL IMAGING S.J. Gwyther INTRODUCTION LUNG CANCER BREAST CANCER COLORECTAL CANCER LYMPHOMAS PANCREATIC CANCER PROSTATE CANCER GYNECOLOGICAL CANCERS Ovarian Cancer Endometrial Cancer Cervical Cancer HEAD AND NECK CANCERS THYROID CANCER RENAL AND BLADDER TUMORS PRIMARY INTRACRANIAL TUMORS CONCLUSIONS REFERENCES 3. TUMOR GENE THERAPY: MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY Mikko I. Kettunen and Olli H.J. Grohn INTRODUCTION TUMOR GENE THERAPY: MAGNETIC RESONANCE IMAGING Endogenous Magnetic Resonance Imaging Contrast Exogenous Contrast Agents MAGNETIC RESONANCE SPECTROSCOPY DETECTION OF TRANSGENE DELIVERY AND EXPRESSION USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY DETECTION OF GENE THERAPY RESPONSE USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY Volumetric Imaging Endogenous Contrasts Sodium Magnetic Resonance Imaging Molecular Imaging Magnetic Resonance Spectroscopy of Metabolic Alterations SUMMARY REFERENCES 4. ASSESSMENT OF GENE TRANSFER: MAGNETIC RESONANCE IMAGING AND 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY Annette Altman and Uwe Haberkorn INTRODUCTION MOLECULAR IMAGING MODALITIES FOR GENE EXPRESSION MOLECULAR IMAGING OF SUICIDE GENE TRANSFER AND THERAPEUTIC EFFECTS MOLECULAR IMAGING SUBSTRATE UPTAKE AFTER SUICIDE GENE TRANSDUCTION NONINVASIVE IMAGING OF REPORTER GENE TRANSFER REFERENCES 5. ROLE OF TP53 MUTATIONS IN CANCER (AN OVERVIEW) Franck Toledo INTRODUCTION IMPACT OF TP53 MUTATIONS ON P53 TRANSACTIVATION CAPACITY OTHER EFFECTS OF TP53 MUTATIONS TP53 MUTATIONS AND THE ETIOLOGY OF HUMAN CANCERS PROGNOSTIC AND PREDICTIVE VALUE OF TP53 MUTATIONS CORRECTION OF P53 PATHWAY IN TUMORS FUTURE PERSPECTIVES REFERENCES 6. PERSONALIZED CANCER MEDICINE (AN OVERVIEW) Sarah J. Welsh and Garth Powis INTRODUCTION WHY IS PERSONALIZED MEDICINE IMPORTANT IN CANCER? TO WHAT EXTENT IS CANCER MEDICINE ALREADY PERSONALIZED? FUTURE OF PERSONALIZED MEDICINE IN CANCER CHALLENGES FOR ACHIEVING PERSONALIZED MEDICINE REFERENCES 7. RADIATION DOSES TO PATIENTS USING COMPUTED RADIOGRAPHY, DIRECT DIGITAL RADIOGRAPHY, AND SCREEN-FILM RADIOGRAPHY Gaetano Compagnone INTRODUCTION RADIATION QUANTITIES USED IN PATIENT DOSIMETRY CONVENTIONAL SCREEN-FILM SYSTEMS PATIENT DOSE AND IMAGE QUALITY WITH CONVENTIONAL SCREEN-FILM SYSTEMS COMPUTED RADIOGRAPHY PATIENT DOSE AND IMAGE QUALITY WITH COMPUTED RADIOGRAPHY DIRECT DIGITAL RADIOGRAPHY PATIENT DOSE AND QUALITY WITH DIRECT DIGITAL RADIOGRAPHY CONCLUSIONS REFERENCES 8. CANCER VACCINES AND IMMUNE MONITORING (AN OVERVIEW) Zsuzsanna Tabi and Stephen Man INTRODUCTION PROPHYLACTIC CANCER VACCINES Vaccines

Cancer killed 6.7 million people around the world in 2002. This book discusses in detail all aspects of lung cancer and prostate cancer. It is the first book that discusses cancer diagnosis, therapy, and prognosis together in one volume.