Clinical immunology : principles and practice/ edited by Robert R. Rich, Thomas A. Fleisher,Harry W. Schroeder,Cornelia M. Weyand,David B. Corry,Jennifer M. puck.

previous editions copyrighted 2019,2013,2008 and 2001

Includes bibliographical references and Index

CONTENTS
PART I Principles of Immune Response--1 The Human Immune Response--2 Organization of the Immune System--3 Innate Immunity--4 Antigen Receptor Genes, Gene Products, and Co-Receptors--5 The Major Histocompatibility Complex--6 Antigens and Antigen Presentation--7 B-Cell Development and Differentiation--8 Immunoglobulin Function--9 T-Cell Development--10 T-Cell Activation and Tolerance--11 Helper T-Cell Subsets and Control of the Inflammatory Response--12 Cytotoxic T Lymphocytes and Natural Killer Cells--13 Regulatory Immune Cells--14 Cytokines and Cytokine Receptors--15 Chemokines and Chemokine Receptors--16 Lymphocyte Adhesion and Trafficking--17 Death Pathways and Immunogenicity--PART II Fundamentals of Host-Environmental Interactions--18 Human Genomics in Immunology--19 Regulatory RNA in Immunologic Diseases--20 Immunometabolism--21 Immune Deficiencies at the Extremes of Age--22 The Microbiota in Immunity and Inflammation--PART III Host Defenses to Infectious Agents--23 Immunology of the Skin24 Immunology of Mucosal Surfaces--25 Host Defenses to Viruses--26 Host Defenses to Intracellular Bacteria--27 Host Defenses to Extracellular Bacteria, Including Spirochetes--28 Host Defenses to Fungi--29 Host Defenses to Protozoa-3--0 Host Defenses to Helminth Infection--31 Emerging Pandemic Infectious Disease Threats--PART IV Immune Deficiency and Immune Regulatory Disorders--32 Approach to the Evaluation of the Patient With Suspected Immunodeficiency--33 Primary Antibody Deficiencies--34 Primary T-Cell Immunodeficiencies--35 Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-?B-Mediated Immunity--36 Hemophagocytic Lymphohistiocytosis--37 Autoinflammatory Syndromes--38 Immune Regulatory Disorders--39 Neutrophils and Neutrophil Disorders--40 Complement and Complement Disorders--41 Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome--42 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases--PART V Allergic Diseases--43 Allergic Airway Diseases--44 Mast Cells and Mast Cell Disorders--45 Eosinophils and Eosinophilic Disorders--46 Urticaria, Angioedema, and Anaphylaxis--47 Allergic Reactions to Stinging and Biting Insects--48 Atopic and Contact Dermatitis--49 Food Allergy--50 Drug Hypersensitivity--PART VI Systemic Immune Diseases--51 Mechanisms of Autoimmunity--52 Systemic Lupus Erythematosus--53 Rheumatoid Arthritis--54 Juvenile Idiopathic Arthritis--55 Sjögren's Syndrome--56 Scleroderma-Systemic Sclerosis--57 Inflammatory Muscle Diseases--58 Spondyloarthritis--59 Small- and Medium-Vessel Primary Vasculitis--60 Large Vessel Vasculitides--61 Antiphospholipid Syndrome--PART VII Organ-Specific Inflammatory Disease--62 Immunohematologic Disor--72 Immunologic Lung Diseases, 91973 Chronic Obstructive Pulmonary Disease and Emphysema--74 Immunologic Ocular Disease--75 Immunologic Diseases of the Gastrointestinal Tract--76 Inflammatory Hepatobiliary Diseases--PART VIII Immunology and Immunotherapy of Neoplasia--77 Lymphoid Leukemias--78 Lymphomas--79 Monoclonal Gammopathies--80 Immune Responses to Solid Tumors and Immune Checkpoint Therapy--81 CAR T-Cell Therapy--PART IX Medical Management of Immunological Diseases--82 Immunoglobulin Therapy: Replacement and Immunomodulation--83 Glucocorticoids--84 Immunomodulating Drugs--85 Protein Kinase Antagonists--86 Biologic Response Modifiers--87 Vaccines--88 Allergen Immunotherapy for Allergic Diseases--PART X Transplantation--89 Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance--90 Allogeneic Transplantation for Immunodeficiency--91 Gene Therapy for Primary Immune Deficiency Diseases--92 Hematopoietic Stem Cell Transplantation for Malignant Diseases--PART XI Diagnostic Immunology--93 Flow Cytometry--94 Assessment of Functional Immune Responses in Lymphocytes--95 Assessment of Neutrophil Function--96 Assessment of Human Allergic Diseases--Appendix 1: Selected CD Molecules and Their CharacteristicsAppendix 2: Laboratory Reference ValuesIndex

Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. Provides new genetics content focused on data applications. Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. Summarizes promising research and development anticipated over the next 5-10 years with "On the Horizon" boxes and discussions of translational research. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud'