Clinical pharmacokinetics and pharmacodynamics : concepts and applications / Malcolm Rowland and Thomas N. Tozer.
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TextPublication details: Philadelphia : Lippincott William & Wilkins, c2011.Edition: 4th edDescription: xxii, 839 p. ; 26 cm. illISBN: - 9780781750097
- RM301.5.R68 2011
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Rev. ed. of: Clinical pharmacokinetics. 1995.
Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data.
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