An introduction to medicinal chemistry / Graham L. Patrick.

includes bibliographical references and index

Drugs and drug targets
an overview
Drug targets : structure and function
Protein structure and function
Enzymes: structure and function
Receptors: structure and function
Receptors and signal transduction
Nucleic acids: structure and function
Pharmacodynamics and pharmacokinetics
Enzymes as drug targets
Receptors as drug targets
Nucleic acids as drug targets
Miscellaneous drug targets
Pharmacokinetics and related topics
Statins
Drug discovery, design, and development
Drug discovery: finding a lead
Drug design: optimizing target interactions
Drug design: optimizing access to the target
Getting the drug to market
The design of ACE inhibitors
Artemisinin and related antimalarial drugs
The design of oxamniquine
Tools of the trade
Combinatorial synthesis
Computers in medicinal chemistry
Quantitative structure-activity relationships (QSAR)
De novo design of a thymidylate synthase inhibitor
Selected topics in medicinal chemistry
Antibacterial agents
Antiviral agents
Anticancer agents
Cholinergics, anticholinergics, and anticholinesterases
Drugs acting on the adrenergic nervous system
Opioid analgesics
Antiulcer agents
Steroidal anti-inflammatory agents
Design of a novel antidepressant

This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug