Medical pharmacology and therapeutics / Derek G. Waller, Andrew G. Renwick, Keith Hillier ; illustrations by Hardlines, Oxford, and Ian Ramsden.

Includes bibliographical references and index.

Preface vii
Acknowledgements viii
Drug dosages and nomenclature ix
SECTION 1 General principles
Sites and mechanisms of drug action
3 (14)
Pharmacokinetics
17 (32)
Drug discovery, evaluation and safety
49 (8)
The nervous system, neurotransmission and the peripheral autonomic nervous system
57 (30)
SECTION 2 The cardiovascular system
Ischaemic heart disease
87 (16)
Hypertension
103 (20)
Heart failure
123 (12)
Cardiac arrhythmias
135 (18)
Cerebrovascular disease and dementia
153 (8)
Peripheral vascular disease
161 (6)
Haemostasis
167 (20)
SECTION 3 The respiratory system
Asthma and chronic obstructive pulmonary disease
187 (16)
Respiratory disorders: cough, respiratory stimulants, cystic fibrosis and neonatal respiratory distress syndrome
203 (8)
SECTION 4 The renal system
Diuretics
211 (12)
Disorders of micturition
223 (8)
Erectile dysfunction
231 (8)
SECTION 5 The nervous system
General anaesthetics
239 (10)
Local anaesthetics
249 (6)
Opioid analgesics and the management of pain
255 (14)
Anxiolytics, sedatives and hypnotics
269 (10)
The major psychotic disorders: schizophrenia and mania
279 (12)
Depression
291 (14)
Epilepsy
305 (14)
Extrapyramidal movement disorders and spasticity
319 (12)
Other neurological disorders: multiple sclerosis, motor neuron disease and Guillain--Barre syndrome
331 (4)
Migraine
335 (10)
SECTION 6 The musculoskeletal system
The neuromuscular junction and neuromuscular blockade
345 (8)
Myasthenia gravis
353 (4)
Non-steroidal anti-inflammatory drugs
357 (12)
Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis
369 (10)
Hyperuricaemia and gout
379 (8)
SECTION 7 The gastrointestinal system
Nausea and vomiting
387 (10)
Dyspepsia and peptic ulcer disease
397 (12)
Inflammatory bowel disease
409 (6)
Constipation, diarrhoea and irritable bowel syndrome
415 (8)
Liver disease
423 (8)
Obesity
431 (6)
SECTION 8 The immune system
The immune response and immunosuppressant drugs
437 (10)
Antihistamines and allergic disease
447 (10)
SECTION 9 The endocrine system and metabolism
Diabetes mellitus
457 (14)
The thyroid and control of metabolic rate
471 (6)
Calcium metabolism and metabolic bone disease
477 (8)
Pituitary and hypothalamic hormones
485 (12)
Corticosteroids (glucocorticoids and mineralocorticoids)
497 (10)
Female reproduction
507 (18)
Androgens and anabolic steroids
525 (6)
Anaemia and haematopoietic colony-stimulating factors
531 (10)
Lipid disorders
541 (14)
SECTION 10 The skin and eyes
Skin disorders
555 (10)
The eye
565 (12)
SECTION 11 Chemotherapy
Chemotherapy of infections
577 (58)
Chemotherapy of malignancy
635 (30)
SECTION 12 General features: toxicity and prescribing
Drug toxicity and overdose
665 (14)
Drug abuse and dependence
679 (12)
Prescribing, adherence and information about medicines
691 (4)
Drug therapy in special situations
695 (8)
Self-assessment answers 703 (46)
Index 749

ntroductory textbook provides a basis for learning about safe and effective prescribing of modern medicines. Includes fundamental descriptions of the disease or condition, where and how drugs have their actions and unwanted effects, and the therapeutic principles of drug use. Full-color format