Aulton's Pharmaceutics/ The Design and Manufacture of Medicines

Includes Bibliographical references and Index

Preface ....................................................................... vii
Contributors ............................................................. ix
Acknowledgements .................................................. xiii
What is 'pharmaceutics'?......................................... xv
Kevin M.G. Taylor and Michael E. Aulton
1. Design of dosage forms.................................. 1Peter York
2. Dissolution and solubility ............................. 13Michael E. Aulton
3. Properties of solutions ................................... 30Michael E. Aulton4. Surfaces and interfaces ................................... 39Graham Buckton5. Disperse systems.............................................. 50David Attwood6. Rheology........................................................... 81Christopher Marriott7. Kinetics ............................................................. 101Gareth R. Williams and John P. Malkinson8. Solid-state properties .................................... 114Graham Buckton9. Particle size analysis ..................................... 126Kevin M.G. Taylor10. Particle size reduction and sizeseparation....................................................... 143Michael E. Aulton11. Mixing............................................................. 156Andrew M. Twitchell12. Powder flow................................................... 172Michael E. Aulton13. Fundamentals of microbiology................... 184Lara-Marie Barnes and Geoffrey W. Hanlon14. Pharmaceutical applications ofmicrobiological techniques.......................... 208Lara-Marie Barnes and Norman A. Hodges15. Action of physical and chemical agentson microorganisms....................................... 229Lara-Marie Barnes, Geoffrey W. Hanlon andNorman A. Hodges16. Principles of sterilization ............................. 247Susannah E. Walsh, Katie Laird and Jean-YvesMaillard17. Sterilization in practice ................................ 257Jean-Yves Maillard, Katie Laird and Susannah E.Walsh18. Introduction to biopharmaceutics.............. 275Marianne Ashford and Kevin M.G. Taylor19. Gastrointestinal tract e physiology anddrug absorption............................................. 279Marianne Ashford and Kevin M.G. Taylor20. Bioavailability e physicochemical,dosage form and formulation factors ........ 297Marianne Ashford, Kevin M.G. Taylor andHala M. Fadda21. Assessment of biopharmaceuticalproperties ....................................................... 320Marianne Ashford and Kevin M.G. Taylor22. Dosage regimens ........................................... 343Soraya Dhillon and Nkiruka Umaru23. Pharmaceutical preformulation .................. 360Simon Gaisford24. Solutions ........................................................ 386Sudaxshina Murdan25. Clarification ................................................... 397Andrew M. Twitchell26. Suspensions ................................................... 407Susan A. Barker27. Emulsions and creams ................................. 424Gillian M. Eccleston28. Ointments, pastes, gels, cutaneouspatches and topical sprays........................... 453Majella E. Lane29. Powders, granules and granulation ............ 463Michael E. Aulton30. Drying............................................................. 483Michael E. Aulton and Satyanarayana Somavarapu31. Tablets and compaction............................... 501Goeran Alderborn and Goeran Frenning32. Modified-release oral drug delivery ............ 542Emma L. McConnell, Christine M. Madla andAbdul W. Basit33. Coating of tablets and multiparticulates ... 558Stuart C. Porter34. Continuous manufacturing of tablets ........ 574Aktham Aburub and Hala M. Fadda35. Hard capsules ................................................ 586Brian E. Jones36. Soft capsules .................................................. 599Stephen Tindal37. Dissolution testing of solid dosageforms............................................................... 612Ana Cristina Freire, Francesca K.H. Gavins andAbdul W. Basit38. Parenteral drug delivery ............................... 626Robert Lowe39. Pulmonary drug delivery ............................. 641Kevin M.G. Taylor40. Nasal drug delivery....................................... 658Gary P. Martin and Alison B. Lansley41. Ocular drug delivery..................................... 677Hala Fadda, Ashkan Khalili, Peng Tee Khaw andSteve Brocchini42. Otic drug delivery ......................................... 701Xu Liu, Hugh Smyth and Feng Zhang43. Topical and transdermal drug delivery ...... 713Adrian C. Williams44. Rectal and vaginal drug delivery................. 735Kalliopi Dodou45. Preparation and delivery ofbiopharmaceuticals....................................... 752Ijeoma F. Uchegbu and Andreas G. Schatzlein46. Pharmaceutical nanotechnology andnanomedicines .............................................. 768Yvonne Perrie47. Radiopharmaceuticals................................... 789Neil Hartman and Margaret Cooper48. The formulation and manufacture ofplant medicines............................................. 805G. Brian Lockwood49. Design and administration of medicinesfor paediatric and geriatric patients............ 818Catherine Tuleu, Mine Orlu and David Wright50. Packaging ....................................................... 833Sudaxshina Murdan51. Chemical stability in dosage forms............ 848Andrew R. Barnes and Mark Santillo52. Microbial contamination, spoilage andpreservation of medicines............................ 860Norman A. Hodges and Lara-Marie Barnes53. Product stability and stability testing......... 871Paul Marshall54. Pharmaceutical quality: the applicationof pharmaceutics in medicinesregulation ....................................................... 894Kevin M.G. Taylor, Majella E. Lane andKhalid A. SheikhSelf-assessment questionsSudaxshina MurdanPlease check your eBook at https://studentconsult.inkling.com/ for self-assessment questions. See insidecover for registration details.Index.......................................................................... 915

A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. Pharmaceutics in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of those areas